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Misra, R. and Das, M. and Sahoo, B. S. (2014) Reversal of multidrug resistance in vitro by co-delivery of MDR1 targeting siRNA and doxorubicin using a novel cationic poly (lactide-co-glycolide) nanoformulation. International Journal Of Pharmaceutics, 475 (1-2). pp. 372-384.

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Over expression of drug efflux transporters such as P-glycoprotein (P-gp) cumulatively leading to multidrug resistance (MDR) embodies a major hindrance for successful cancer therapy. A paradigm nanomedicinal approach involving an anticancer drug and modulators of drug resistance within one multifunctional nanocarrier-based delivery system represent an ideal modality for the treatment of MDR. In this regards, we have developed a cationic polymeric nanoparticulate system loaded with MDR1-siRNA and doxorubicin. Results indicated augmented synergistic effect of combinational nano-formulation in overcoming MDR in MCF-7/ ADR cells. Therefore, the above regime could be a promising co-delivery system for effective therapy of drug resistant breast cancer. (C) 2014 Elsevier B.V. All rights reserved.

Item Type: Article
Subjects: Genomics
Depositing User: Unnamed user with email alok@urdip.res.in
Date Deposited: 27 Mar 2015 05:23
Last Modified: 27 Mar 2015 05:23
URI: http://ils.sciencecentral.in/id/eprint/3

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